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Vol: 51(65) No: 1 / March 2006       On the Use of Robust Servo Control In Diabetes Under Intensive Care Levente Kovacs Department of Control Engineering and Information Technology, Budapest University of Technology and Economics, Faculty of Electrical Engineering and Informatics, H-1117 Budapest, Magyar Tudósok krt. 2, Hungary, phone: (36-1) 463-4027, e-mail: lkovacs@iit.bme.hu Balazs Kulcsar Department of Transport Automation, Budapest University of Technology and Economics, Faculty of Transportation Engineering, H-1111 Budapest, Bertalan Lajos u. 2, Hungary, phone: (36-1) 463-2255, e-mail: kulcsar@kaut.kka.bme.hu Zoltan Benyo Department of Transport Automation, Budapest University of Technology and Economics, Faculty of Transportation Engineering, H-1111 Budapest, Bertalan Lajos u. 2, Hungary Keywords: diabetes mellitus, glucose-insulin control, robust control, multiplicative uncertainty, μ-synthesis method. Abstract The robust servo control of a model-based biomedical application, namely the glucose-insulin control of diabetes patients under intensive care, is presented in the paper. The synthesis and analysis is based on a modified two compartment Bergman model and realized with a two degree of freedom controller structure permitting to assure insulin tracking. The augmented Δ − P − K structure is described with the necessary weighting functions. A non-conservative complex μ-synthesis method is applied. Using the controller, not only the robust stability is met under multiplicative uncertainty, but also the nominal performance i.e. the disturbance rejection is fulfilled. Food (sugar) intake is considered as disturbance. Closed loop simulation results are edged for optimizing the insulin amount. References [1] G. van den Berghe, “Insulin therapy for the critically ill patient”, Clinical Cornerstone, vol. 5/2, pp. 56 – 63, 2003. [2] B. N. Bergman, Y. Z. Ider, C. R. Bowden and C. 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